(The Carolinian) — A groundbreaking study led by researchers at Brigham and Women’s Hospital and Duke University sheds light on the significant health risks posed by the V142I transthyretin variant within the US Black population. Published in the JAMA Network, the study underscores the concerning impact of this genetic variant on heart health and longevity.
“The V142I transthyretin variant, prevalent in three to four percent of self-identified Black individuals in the US, is associated with an increased risk of heart failure and death,” explained lead author Dr. Senthil Selvaraj from Duke University School of Medicine. Drawing from data from over 20,000 self-identified Black individuals, the study estimates that carriers of this variant could collectively lose approximately a million years of life.
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